"That would be a tremendous final if we both made it through," said Neath skipper Paul Jones (prop).
"There's been plenty of passion between the two clubs already this season but a third meeting in Cardiff would settle it. But first we must win our semi-final to think about a possible game against the Wizards.
"Over the years we have enjoyed some memorable days out in Cardiff and hopefully we could give the fans another and comeback with some silverware.
"Hopefully by then we would be going for the league and cup double. We have to hope Newport slip up in the league but right now the chance is still there and we won't take our foot off the pedal."
Neath coach Rowland Phillips said (before the draw):
"The cup this season has shown that people's passion and interest is as high as ever. It is a competition that Neath have been successful in over the years.
"It is also now the only competition where we have control over our own destiny, as in the league we need others to do favours for us in beating Newport."
Caerphilly coach Roger Bidgood, the former Wales centre, stated: "I did not won a semi-final as a player, so I hope we can go on to secure a final place."
Semi-final draw: Neath v Brynmawr/Bridgend; Cross Keys/Aberavon v Caerphilly To be played April 17th & 18th at the Millennium Stadium, Cardiff.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.