"That would be a tremendous final if we both made it through," said Neath skipper Paul Jones (prop).
"There's been plenty of passion between the two clubs already this season but a third meeting in Cardiff would settle it. But first we must win our semi-final to think about a possible game against the Wizards.
"Over the years we have enjoyed some memorable days out in Cardiff and hopefully we could give the fans another and comeback with some silverware.
"Hopefully by then we would be going for the league and cup double. We have to hope Newport slip up in the league but right now the chance is still there and we won't take our foot off the pedal."
Neath coach Rowland Phillips said (before the draw):
"The cup this season has shown that people's passion and interest is as high as ever. It is a competition that Neath have been successful in over the years.
"It is also now the only competition where we have control over our own destiny, as in the league we need others to do favours for us in beating Newport."
Caerphilly coach Roger Bidgood, the former Wales centre, stated: "I did not won a semi-final as a player, so I hope we can go on to secure a final place."
Semi-final draw: Neath v Brynmawr/Bridgend; Cross Keys/Aberavon v Caerphilly To be played April 17th & 18th at the Millennium Stadium, Cardiff.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.
Wales Sevens head coach Gareth Williams looks back on the Rio Sevens success where he helped GB win silver. He believes the successful campaign is a huge boost to his Welsh squad as they prepare for another World Series, as WRU TV's Graeme Gillespie discovers
British and Irish Lions head coach Warren Gatland will be heading back home to take on the All Blacks next year where for him, success for 2017 is all about going to New Zealand and winning a Test Series.
Last week all roads led to Eugene Cross Park where defending champions Ebbw Vale hosted this season's launch of the Principality Premiership. WRU TV's Graeme Gillespie was there to capture the thoughts of Damien Hudd, captain of Ebbw Vale, and WRU Head of Performance, Geraint John.
Llandovery made it three in a row when they defeated Aberavon in the final of the National Foster's 7s at BT Sport Cardiff Arms Park on Sunday. On another eventful day of sevens, Newport claimed the Plate and the Dragons won the women's crown
Last week saw Cardiff welcome players from around the world for the 21st Golden Oldies Festival. The tournament features players over 35 years of age, and this year's event saw a select few represent the WRU in a 'friendly' against the Wooden Spoon.
Wales Under 18 captain Callum Bradbury is delighted to have seen his side claim a narrow 18-17 victory against a strong SA Schools 'A' side to end the three-match Under 19 International Series in South Africa on a high note.
The Wales U18 squad spent an emotional day in the drug-riddled townnship of Hout Bay. Hout Bay Warriors President Fred Johannes said the visit was 'the talk of the town' and will dream about the day everyday for the rest of his life.
RGC 1404's new head coach Mark Jones is hoping to build 'something special' in north Wales and is already looking forward to the development region participating in the Principality Premiership for the very first time.