"That would be a tremendous final if we both made it through," said Neath skipper Paul Jones (prop).
"There's been plenty of passion between the two clubs already this season but a third meeting in Cardiff would settle it. But first we must win our semi-final to think about a possible game against the Wizards.
"Over the years we have enjoyed some memorable days out in Cardiff and hopefully we could give the fans another and comeback with some silverware.
"Hopefully by then we would be going for the league and cup double. We have to hope Newport slip up in the league but right now the chance is still there and we won't take our foot off the pedal."
Neath coach Rowland Phillips said (before the draw):
"The cup this season has shown that people's passion and interest is as high as ever. It is a competition that Neath have been successful in over the years.
"It is also now the only competition where we have control over our own destiny, as in the league we need others to do favours for us in beating Newport."
Caerphilly coach Roger Bidgood, the former Wales centre, stated: "I did not won a semi-final as a player, so I hope we can go on to secure a final place."
Semi-final draw: Neath v Brynmawr/Bridgend; Cross Keys/Aberavon v Caerphilly To be played April 17th & 18th at the Millennium Stadium, Cardiff.
Dodgy tattoos, carthorses, Avatar and soft chins are revealed by Wales Sevens players Tom Williams and Sam Cross as they profile the Wales Sevens squad taking part in Hong Kong this weekend in the latest round of the HSBC Sevens World Series.
The youngest member of the Wales Women's squad, Keira Bevan, is hoping to repay the faith shown in her when she starts her first Six Nations game against Italy tomorrow evening in the final round of the championship.
Sevens head coach Gareth Williams is a happy man after drafting in full internationals Rhodri Williams and Adam Warren for the next two rounds of the world series in Hong Kong and Japan, as WRU TV's Graeme Gillespie discovers.
Gemma Rowland has had a 'whirlwind' start to her international career with Wales. Despite losing to France, she is confident Wales Women can bounce back and claim a rare Triple Crown against Ireland on Sunday, as WRU TV's Graeme Gillespie discovers.