Llanharan travel to Ebbw Vale to meet Tredegar as the latter's pitch is out of action. This is fourth different venue in successive home matches for Tredegar.
The other unbeaten club, leaders Maesteg, will have a home match against Blackwood and the top two get nearer to a showdown at the Dairy Field in a few weeks time.
Rumney go looking for their first-ever win at Parc Mawr against Bonymaen on a day when home side look favourites in most of the games, though the Tondu versus Brynmawr game is off due to Brynmawr's cup tie on Sunday at home to Bridgend.
West leaders Tonmawr travel to Bridgend Athletic for an important league outing, while Dunvant face a tricky home match against Cwmllynfell.
In the East, new leaders Builth Wells will travel to bottom club Penygraig, who conceded 150 points last week against Llantrisant. Second-placed Merthyr face a tough battle away to Croesyceiliog.