Griffiths says the 42-0 win over a star-studded Barbarians side in Bristol last month - the first time Wales have kept their opponents scoreless since a 54-0 romp over minnows Spain 10 years ago - was a terrific result, but things would be a lot tougher this weekend.
"The Pumas are very powerful men who like to take route one," he said. "We'll have to be spot-on technically and tactically to repel those attacks and to frustrate them.
"There were great signs in the game against the Barbarians - the most pleasing aspect for me was the return we got from the technique work we'd done because there had been a fall-off in that area.
"We're still banging the drum in terms of fronting up individually and then teaming up. We know that they're aiming to power over us - we have to relish the challenge and show them we can stand up to it."
Griffiths' system - which uses a flat, flirting-with-offside rushing line in defence combined with aggressive tackling - was the star of the show at Ashton Gate last month.
"We tried something and it worked and I'm delighted, but one swallow doesn't make a summer," he said. "Our feet are firmly on the ground - let's wipe the slate clean and go again.
"Having said that, if we get our set-piece right and our defence right, they're going to have a hard time of it. We've got the players out wide to make them pay."
Griffiths said there were plusses and minuses about Argentina's love of 10-man rugby.
"They are predictable but you've got to be ready for the hidden punches - and I don't mean the illegal stuff. I mean everyone's expecting them to go down the narrow channels, but a couple of balls wide and bang, they've caught you out if your line's not right.
"When they do things right, the Pumas are difficult to stop. We have to make the tackles and if we do that, they'll be playing behind the gain-lines and they won't enjoy that."
Griffiths said the BaaBaas' zero scoreline was the ultimate reward for the work his players are doing on the tackle bags.
"It's very difficult to stop teams scoring points at international level. It's nigh on impossible, but we did do it, which is a great plus for us. To nil a team is a great source of satisfaction and to stop that Barbarians juggernaut was great for the boys' confidence. The pride in the defence to keep that nil score was fantastic.
"We're going out there this weekend with a no-tries attitude - which is very difficult to achieve at Test level. If a team like Argentina gets a five-metre scrum and does things right, it's very difficult to keep them out, but we're keen to do just that."
Griffiths said outside centre Sonny Parker was proving to be a key player in the battle to keep the Welsh try-line intact.
"I've given him bigger responsibilities because he has to come out of his shell. With our type of our defence, the No 13 is a very important.
"Sonny is a quiet bloke off the field, but we'll see a bit of Jekyll and Hyde in him when he gets out there against the big boys."