The Blues only victory in the eight Welsh Derbies they played last season was when they beat the Ospreys 43-6 at the Arms Park last October.
The Dragons make their bow in this year's Celtic League after receiving a bye last week. They lost the final match of last season in Dublin which snapped a six match winning run in the competition. Newport Gwent Dragons won both matches against the Blues last campaign.
Blues: R Willims; J Vaughton, T Shanklin, T Davies, C Morgan; L Thomas, R Smith; G Jenkins, G Williams, B Evans, C Quinnell, R Sidoli, N Thomas, M Williams (capt), K Schubert.
Replacements: J Yapp, M Leaman, M Jones, D Jones, M Lewis, D Dewdney, N Macleod.
Dragons: K Morgan; G Wyatt, H Luscombe, J Bryant, N Brew; C Sweeney, G Baber; R Snow, S Jones, C Anthony, I Gough, M Owen, J Ringer, J Forster (capt), R Bryan.
Replacements: S Tuipulotu, G Cooper, A Black, J Richards, R Thomas, P Sidoli, R Beattie.
Referee: Alain Rolland (Ireland)