The two unbeaten clubs in the North are both away as Bala visit Bangor and Machynlleth go to Bro Ffestiniog with the old meeting the new as Wrexham entertain Rhayader.
Five clubs are unbeaten in the South-West and two clash as Neath Athletic meet Cwmgwrach, while Porthcawl against Cefn Cribbwr will provide at least one club with a first point.
An interesting match will be at Porth, where the Quins take on a resrgent Ogmore Vale, inspired by fly half Mike Huntley and Ferndale have the task of holding powerful newcomers Penallta. In the West, unbeaten New Dock Stars and Penygroes are at home and Aberaeron visit Tycroes.
Match of the day in the East is certainly at Nantyglo, where the reformed Abertillery BG are the visitors and St Alban's look to carry on winning at Blaenavon.
A special video package as Pontypridd claimed the double for the first time in their history by winning the Principality Premiership final, including match build-up, highlights, post match reaction and dressing room celebrations.