The two unbeaten clubs in the North are both away as Bala visit Bangor and Machynlleth go to Bro Ffestiniog with the old meeting the new as Wrexham entertain Rhayader.
Five clubs are unbeaten in the South-West and two clash as Neath Athletic meet Cwmgwrach, while Porthcawl against Cefn Cribbwr will provide at least one club with a first point.
An interesting match will be at Porth, where the Quins take on a resrgent Ogmore Vale, inspired by fly half Mike Huntley and Ferndale have the task of holding powerful newcomers Penallta. In the West, unbeaten New Dock Stars and Penygroes are at home and Aberaeron visit Tycroes.
Match of the day in the East is certainly at Nantyglo, where the reformed Abertillery BG are the visitors and St Alban's look to carry on winning at Blaenavon.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.