The two unbeaten clubs in the North are both away as Bala visit Bangor and Machynlleth go to Bro Ffestiniog with the old meeting the new as Wrexham entertain Rhayader.
Five clubs are unbeaten in the South-West and two clash as Neath Athletic meet Cwmgwrach, while Porthcawl against Cefn Cribbwr will provide at least one club with a first point.
An interesting match will be at Porth, where the Quins take on a resrgent Ogmore Vale, inspired by fly half Mike Huntley and Ferndale have the task of holding powerful newcomers Penallta. In the West, unbeaten New Dock Stars and Penygroes are at home and Aberaeron visit Tycroes.
Match of the day in the East is certainly at Nantyglo, where the reformed Abertillery BG are the visitors and St Alban's look to carry on winning at Blaenavon.
The Wales Women's team headed to Dare Valley Country Park on a team bonding exercise as the entire squad got together for the very first time in preparation for this season's Six Nations championship which kicks off on Saturday with a clash against defending champions Ireland, in Donnybrook.
Wales Head Coach Warren Gatland discusses his team selection for the opening round of the RBS 6 Nations where he leads his side against Ireland, on Sunday. As WRU TV's Luke Brodley discovers, Gatland is fully aware of the challenges the defending champions pose
WRUTV caught up with Wales Women captain Rachel Taylor at the RBS 6 Nations launch and how a good crowd really helps boost the girls performance. Tickets for all three Women's home games at The Gnoll, Neath are available from www.wru.wales/tickets
The WRU Coach Core Apprenticeship scheme is developing young people who are already benefitting Welsh rugby while improving their own career prospects. WRU TV caught up with some of the individuals who are making a difference.
The Wales Sevens squad had some spare time to kill while waiting for a training session in Dubai, so decided to play: Let's head a football into a rubbish bin. It seemed such a simple idea at the time....