Local rivals St Peter's and Cardiff HSOB play a match at the Harlequins Ground, where the 'Rocks' are the hosts, but on a pitch that was once the home of the Old Boys.
Also in the East, Monmouth will be challenged strongly on their fine pitch by Newport HSOB. Something has to give in the West as Milford Haven and Betws near the bbottom of the table, while Amman United face a stern test at home to Llandybie.
Fairwater, yet to concede a point, go to Dowlais in the South-East and Bishops Field will be the scene for a clash of unbeaten clubs Llandaff and enarth, with Rhigos taking on Cowbridge near the foot of the table.
Chris O'Callaghan takes over as Diirector of Rugby at Aberavon Green Stars, who should gain a win at Pyle in the South-West in a Division where Resolven entertain Maesteg Celtic, while in the North, Nant Conwy have a chance for a first win as they take on Dolgellau.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.