There are home matches for three of the new boys as Builth Wells, Bridgend Athletic and Fleur de lys entertain Carmarthen Athletic, UWIC and Narberth respectively. For Bridgend Athletic it will their debut in this division, having been byed last Saturday.
Glamorgan Wanderers are capable of shocking Maesteg; Llangennech could be too powerful for Blackwood and Beddau will use home advantage over Tonmawr, while Whitland and Brynmawr could be a close affair.
Brynithel's win at Merthyr will make visitors Abercynon cautious in the East, while the Ironmen make the trip to Tredegar and the most interesting match will be at The Oval, Treorchy, where Rumney's fast, young side are welcomed.
Dunvant should have a high-scoring affair against Corus in the West, where the match of the day may be at Mumbles, who take on powerful-looking Felinfoel and a lively affair will see Waunarlwyd facing Kidwelly.