Leaders Carmarthen Quins are unbeaten after three matches and visit Caerphilly, who have lost all three games, but the division is still far from settled and the Cheesemen are quite capable of causing an upset at Virginia Park.
The big clash must be at the Arms Park, where Cardiff entertain Newport in what could prove a high-scoring match after Newport hung on to their unbeaten tag on Wednesday with a try by former Cardiff forward Darren Davies.
Bottom club Ebbw Vale meet inconsistent Llanelli at Eugene Cross Park and Pontypool, who have gone close without winning, travel to Aberavon, who may have two players named John Jones and two named Paul Morgan in their squad.
Cross Keys historian Horace Jeffries is ready to launch a second book on the history of the club in two weeks time, but before that comes the derby meeting with Newbridge at Pandy Park, while the other three fixtures will see Bridgend against Bedwas at the Brewery Field; Pontypridd meeting Llandovery at Sardis Road and Swansea taking on Llanharan at St Helen's.
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s