Leaders Carmarthen Quins are unbeaten after three matches and visit Caerphilly, who have lost all three games, but the division is still far from settled and the Cheesemen are quite capable of causing an upset at Virginia Park.
The big clash must be at the Arms Park, where Cardiff entertain Newport in what could prove a high-scoring match after Newport hung on to their unbeaten tag on Wednesday with a try by former Cardiff forward Darren Davies.
Bottom club Ebbw Vale meet inconsistent Llanelli at Eugene Cross Park and Pontypool, who have gone close without winning, travel to Aberavon, who may have two players named John Jones and two named Paul Morgan in their squad.
Cross Keys historian Horace Jeffries is ready to launch a second book on the history of the club in two weeks time, but before that comes the derby meeting with Newbridge at Pandy Park, while the other three fixtures will see Bridgend against Bedwas at the Brewery Field; Pontypridd meeting Llandovery at Sardis Road and Swansea taking on Llanharan at St Helen's.
A special video package as Pontypridd claimed the double for the first time in their history by winning the Principality Premiership final, including match build-up, highlights, post match reaction and dressing room celebrations.