Blaina, led by former Newbridge lock Christian Penny, host Cardiff-based Llanharan, coached for the first time by Shaun Lee, at Central Park in the pick of the East matches and in the South-East eyes will be on Ruthin, who make their debut by playing at Brecon, but the Pentyrch-Tonyrefail game in that division has been called off.
Maesteg Quins will be hoping to host Cwmgors in the South-West after the latter withdrew from the Konica Minolta Cup last week and in the West there looks to be strong competition in all seven matches with Lampeter renewing battle against Loughor in what may be a close affair.
Crymych's fine cup win in Cardiff last week should make them good opponents at Laugharne in the West and last season's Division Five champions Trinant are new faces at Monmouth in a division where the Oakdale-St Peter's clash will be strongly contested.
In the South-East promoted clubs Llandaff North and Llantwit Major are paired together for the opener at Hailey Park and relegated Taffs Well will have lively opponents in Fairwater. South-West action will include Briton Ferry against Aberavon Green Stars and Resolven's trip to Morriston. The North opens with five matches in which the clash at Nant Conwy, where Llangefni are the visitors, should be a key to the whole season.
It will a great day for the new clubs in the League with Rhayader making their debut in the North, away to Llanidloes; Penallta are at Cilfynydd in the South-East, where Porth entertain South Wales Police and Glyncorrwg are the new boys in the South-West and will be facing Crynant.
Biggest clash in the North is at Wrexham where Bala are visitors, while Abertillery BG make a reappearance in the East, playing on the beautiful Abertillery Park against Cardiff-based club St Joseph's, but Blaengarw's return in the South-East is delayed as they are the bye club, as are Pembroke in the West.