The Scarlets, are bidding to make it three Heineken Cup semi-finals in four years.
"Perpignan represent a huge challenge - there are no bad teams left in the tournament," said Gareth Jenkins, the Llanelli Director of Rugby. "These are the best eight sides in Europe at the moment and Perpignan are definitely one of those.
"We have played them three times in the Heineken Cup, winning once and losing twice, and as they were in our Pool last season, we are quite familiar with them.
"However, coach Nigel Davies and I went over to see them a couple of weeks ago, when they were playing Agen, and they are a different side nowadays.
"And that difference is one player - their Australian international fly half Manny Edmonds. He makes them play, he totally runs the show.
"They also have a very physical front five - huge in stature - and he is the one who really makes them tick.
"They will come here believing they can win and anyone thinking it is a foregone conclusion, that we will go through, can think again. We will have to be at our very best to get the result we want."