Another good match-up is at Church Bank, where Llandovery warm up for their Principality Cup meeting with Caerphilly next week by taking on an in-form Bedwas side, in which wings Stefan Sankala and Nathan Hill are excelling.
Leaders Pontypool are at home to Tondu, a dangerous opponent, yet the Gwent side should gain a victory, as Tondu centre Richard Dyke, a former Pooler player, is unlikely to be fit to play.
Carmarthen Quins go to bottom club Treorchy with Paul Fisher, on loan from Llanelli, at fly half as Giles Thomas takes a break on the bench. Forward Danzi Niblo is fit again to return to the Quins pack after a four-month absence.
There could be fireworks at Newbridge for the return match with neighbours Blackwood, after three Newbridge players were dismissed in the first game that Blackwood won.
Rumney's big effort to gain a second win must come at Beddau in what will be a close encounter. Fly half Chris Day from UWIC is in the Rumney squad with Matthew Spencer having joined Cross Keys.
Cross Keys should defeat Tredegar at Pandy Park, but nothing is certain when Tredegar coaches
Rob and Gareth Johnston return to the club they used to play for. Keys have released flanker Andrew Gibbs, who should soon acquire a new club.
Ever-improving Llanharan should haveRobert Johnson from Pontypridd back on their wing and possibly lock Ryan Jones from Bridgend in their home match with Whitland.
Narberth look for the double over Bonymaen, who have fly-half problems, where they may use former Wales full back Darril Williams, while Narberth fly-half Simon Daniel need a late fitness test to play.