And with nearly 40,000 supporters expected in the Cardiff showpiece stadium, it will be an intriguing contest between two sides that have proved themselves to be the best in Celtic competition.
Munster are hot favourites to lift the crown, but Neath will be cheered on only a few miles from their home ground and have shown this season they have the ability to grind out wins when required.
While Neath have largely relied on the boot of Lee Jarvis in this year's tournament - he has 83 points to date - Munster have utilised the pace in the backs with centre Mike Mullins and winger Mossie Lawlor topping the tournament's try-scoring charts with six each.
With Neath no longer in the Heineken Cup, Lyn Jones' side will see this weekend's final as their best chance of lifting any silverware this season.
Munster have received a timely boost with Ireland and Lions centre Rob Henderson being included in their squad.
Henderson has not played for the Irish province since their Heineken Cup pool defeat to Gloucester at Kingsholm last October when he picked up a bicep injury.
But he played 80 minutes at the weekend and Munster coach Alan Gaffney has added the player to the 22-man squad.
Neath have injury worries to key players, with hooker Steve Jones, backrower Hywel Jenkins and scrum-half Patrick Horgan ruled out of Saturday's game.
THE BATTLE OF THE BOOTS
The key battle of the day will be between Lee Jarvis and Ronan O'Gara. We take a closer look at the men who could be kicking their side to Celtic League glory.
Lee Jarvis (Neath)
Position: Outside Half
Height: 6' 0'
Weight: 14st 7in
International Caps: 1
Celtic League Points: 83
Position: Outside Half
Height 6' 0'
Weight: 13 st
International Caps: 27 (275 points for Ireland)
Celtic League Points: 69
Neath: A Durston; G Morris, J Storey, D Tiueti, S Williams; L Jarvis, A Moore; D Jones, B Williams, A Jones, A Newman, G Llewellyn (capt), A Mocelutu, B Sinkinson, N Bonner-Evans. Replacements: A Matthews, A Millward, L Bateman, R Phillips, S Tandy, S Connor, A Bateman.
Munster: J Staunton, J Kelly, M Mullins, J Holland, M Lawlor; R O'Gara, P Stringer; M Horan, F Sheahan, J Hayes, M O'Driscoll, D O'Callaghan, J Williams (capt), A Quinlan, A Foley. Replacements: J Blaney, M Cahill, M Galwey, D Leamy, M Prendergast, R Henderson, K Keane