Neath-Swansea Ospreys utility Shane Williams is facing a fight to be fit ahead of Wales' final World Cup pool match against New Zealand in Sydney on Sunday.
The Test winger, who can also slot in at scrum-half, was expected to get a run in the eagerly awaited match but is battling the flu.
The news is further bad news for coach Steve Hansen, who lost OspreyS prop Duncan Jones with a fractured fibula during the Italy clash.
Wales won that match 27-15 to secure their place in the World Cup quarter-finals.
Better news for Hansen is that Gareth Thomas, Sonny Parker and Kevin Morgan, who all took knocks in the crucial match against Italy on Saturday, but are all expected to be available for selection this weekend.
Wales have not beaten New Zeland since 1953, but with the All Blacks have been short of competitive matches in this year's cup, giving rise to hope that this could be the hour of success.
The last five years have been an emotional rollercoaster on and off the pitch for RGC1404. Promotion to the Principality Premiership was the culmination of five years of hard work and investment in North Wales. WRU TV caught up with prop Joe Simpson, who was one of the first intake of WRU North Wales Academy players in 2010.
Ebbw Vale captain Damien Hudd picked up the biggest accolade of the night at the 11th Principality Premiership Awards Evening held at Principality Stadium, after leading his side to the title for the first time.
Wales assistant coach Robin McBryde is predicting a tough battle against England on Sunday despite the fact they may not be considered to be at full strength. Players will be out to impress Eddie Jones which makes England a dangerous proposition, he says.
Wales U20 captain Tom Phillips and performance psychologist Dr Rich Neil explain why spending three days at Monmouth RFC has further strengthened the togetherness of the squad ahead of the #WorldRugbyU20s