Neath-Swansea Ospreys utility Shane Williams is facing a fight to be fit ahead of Wales' final World Cup pool match against New Zealand in Sydney on Sunday.
The Test winger, who can also slot in at scrum-half, was expected to get a run in the eagerly awaited match but is battling the flu.
The news is further bad news for coach Steve Hansen, who lost OspreyS prop Duncan Jones with a fractured fibula during the Italy clash.
Wales won that match 27-15 to secure their place in the World Cup quarter-finals.
Better news for Hansen is that Gareth Thomas, Sonny Parker and Kevin Morgan, who all took knocks in the crucial match against Italy on Saturday, but are all expected to be available for selection this weekend.
Wales have not beaten New Zeland since 1953, but with the All Blacks have been short of competitive matches in this year's cup, giving rise to hope that this could be the hour of success.
As the countdown continues for RWC2015, Tournament Chief Executive Debbie Jevans visited the Millennium Stadium to discuss preparations for the eight matches and reveal the positive news that 100,000 tickets for games at the home of Welsh rugby have sold in the last seven days.
Jason Harries is targeting a first win on the World Series circuit this season with Wales. The series returns to action this weekend in Dubai where Harries is part of a team hoping to build from its efforts in round one in October.
Wales skipper Jevon Groves says his side have addressed a few points from Gold Coast and aim to 'hit the ground running' in the next two rounds of the World Series, kicking off with this weekend in Dubai before heading off to South Africa next week.
Wales Sevens manager Steff Thomas is hopeful his side can build from a quarter-final spot in the opening round of the World Series in Australia when his side take part in the forthcoming double header in Dubai and South Africa.