Iestyn Harris is called up to play at inside centre in place of Tom Shanklin and Dwayne Peel takes over from Gareth Cooper at scrum half as Wales seek to avoid a Championship whitewash.
The enforced changes through injuries see Craig Morgan coming in on the wing for Mark Jones and Mefin Davies at hooker in place of Jonathan Humphreys. Flanker Martyn Williams, who captained the side against Scotland, leads Wales for the second time in the absence of Humphreys.
Wales: R Williams (Cardiff); C Morgan (Cardiff), M Taylor (Swansea), I Harris (Cardiff), Gareth Thomas (Bridgend); S Jones (Llanelli), D Peel (Llanelli); I Thomas (Llanelli), M Davies (Pontypridd), G Jenkins (Pontypridd), R Sidoli (Pontypridd), G Llewellyn (Neath), C Charvis (Swansea), M Williams (Cardiff, captain), D Jones (Llanelli).
Replacements: G Williams (Bridgend), M Madden (Llanelli), S Williams (Northampton Saints), Gavin Thomas (Bath Rugby), G Cooper (Bath Rugby), T Shanklin (Saracens), M Watkins (Llanelli).
France remain unchanged