Pontypool go to Narberth and will face problems if Byron is injured in any way, while Aberavon, just clinging on to the lead by one try, visit Newbridge, who downed them last season.
At the bottom, Rumney will try to repeat last season's win over Bonymaen, whose sat\r forward Andy Llewellyn broke his hand two weeks ago. They will await Treorchy's home result to Whitland, whose form is inconsistent these days.
Carmarthen Quins face a Tondu side that is always better with Richard Dyke's presence at inside centre and Cross Keys take having a stern challenge from in -form Bedwas
Llanharan face a pay-back chance at home to Glamorgan Wanderers, who put them out of the Principality Cup, Beddau hope to give Llandovery a shock and Blackwood face a big test at home to Tredegar.
In the lower divisions there are a few battles between the top two sides of a division. One is in Llanelli, where the Wanderers have a home match against leaders Cwmgors in Six West, while Cefneithin go to Seven West leaders Pontyates with two games in hand and a five-point deficit.
The North should see Nant Conwy keep ahead of Five with a match at Ruthin and Bala almost complete the Six title at home to Bro Ffestiniog.
Leaders looking likely to win are Brecon (away to Pontypool United) in Four East, Cwmgwrach (at home to Cwmtwrch) in Seven East and Fairwater (at Crumlin) in Six East, where Banwen meet Cardiff HSOB in a second place battle.
Division Two top dogs Llangennech should beat an indifferent Rhymney in Division Two, where Carmarthen Athletic may have trouble at Brynmawr, while Croesyceiliog lead Penygraig now by just one try in Three East, where the best match may be Ystrad Rhondda against Dinas Powys.
Felinfoel, at home to Seven Sisters, must be confident in Three West, as will Bryncoch at Haverfordwest in Four West, but Five West is open with several interesting matches.
The only unbeaten league club, Nantymoel, go to Pontyclun in Five Central, where Banwen entertain Tylorstown, while Abercwmboi take on Taibach in Six Central.
Newport Saracens should overcome Caldicot in Five East, though Old Illtydians face a tough challenge at Barry's Reservoir Field and Llandaff will do well to win at Bettws in Seven East.