But Ospreys hooker Dewi Lake - who will be captaining his country for the first time - believes his side are in a good place ahead of the clash at the Stadio Danilo Martelli.
"I think there's a lot of positives we can take out of last week," said Lake.
"It was good for us to go against the world champions first up so that we could see where we are at.
"It was 10-10 going into the break at half-time last week but a try after the interval probably gave them a bit of an edge. For 40-60 minutes we did go toe to toe with them so it does give us some confidence as a team.
"We realise the potential we have and what we can do when we play well. There's a lot of positives we can take out of it.
"I thought our scrum and lineout went well and a couple of plays that we had worked on in training came off. I think it's about minimalising our errors to keep Italy out of the game."
Lake knows he has big boots to fill in the absence of inspirational squad captain Tommy Reffell who is out injured.
But he maintains he is up to the task calling it the greatest honour of his career so far.
"It is a very proud moment to captain my country for the first time," he said.
"I don't think there's anybody who would turn down the chance to captain their country especially in a stadium like this.
"The surroundings are unbelievable. It's always going to be different when you travel to different countries because they're going to have different settings.
"It's amazing to see the kind of arena we are playing in. We lost the last time we played against Italy in Colwyn Bay so I'm expecting them to come out firing especially as they are on a high after beating Scotland last weekend."