Wales centre Jonathan Spratt captains the side and is partnered by Andrew Bishop in midfield. Matthew Morgan will be hoping to continue his impressive recent form at fly half. Dirksen makes a welcome return from a long-term injury with a place on the bench.
"This is without doubt a huge game for us. With 13 of our squad on international duty, the team will have a different dynamic to what supporters are perhaps used to," said Tandy.
"The squad have been working hard this week and we as coaches are really pleased with the effort and in particular, the willingness to learn, that the squad's younger players have shown at training.
"Llandarcy has been an exciting place to be this week and everyone is looking forward to the challenge of Thomond Park.
"It's never an easy place to go to, Munster have an enviable history at home and while we are proud of the fact that we are the only non-Irish team to beat Munster there in the Rabo since 2006, its going to be a tough match. They are coming into the game after some very impressive performances and have only lost twice so far this season."
Tandy added: "While Munster are looking strong, we are also going into the game off the back of our victory against the Dragons last week.
"We are still working towards the full performance the result has given the squad confidence, we know what we have to do and I believe from the work put in this week that this group can deliver what we ask of them. We will go to Thomond Park knowing how strong we can be and hopefully we will do ourselves justice."