North starts the final Heineken Cup Pool Five game though centre Scott Williams misses the game with a shoulder problem. He is though expected to join up with the Wales squad as normal on Monday.
In a further boost for Howley, flanker Aaron Shingler is among the replacements following his recovery from a groin problem.
Simon Easterby's side will be looking for their first European win of the season but face a tough ask against the team who beat them 49-16 in France earlier in the competition.
A win for Clermont, who include Wales full back Lee Byrne, would see them guarantee a place in the quarter finals.
Byrne, who has recovered from a fractured vertebrae, faces a direct match up against fellow Six Nations squad member Liam Williams in what should be an interesting head-to-head.