In the SWALEC Cup, last year's beaten finalists Pontypridd face a difficult trip to Llanelli in a match that will see one of Welsh rugby's cup giants exit the competition at the first hurdle.
Ponty fell to a surprise defeat against Cross Keys in last season's final at the Millennium Stadium and will have to overcome the ultimate cup kings, 14 times winners Llanelli on their own patch in order to progress to round two.
Elsewhere, rivals Bridgend and Bridgend Athletic clash at Brewery Field with local bragging rights at stake. The Ravens started their Premiership campaign with a win over Llanelli last weekend but the local derby will surely bring out the best in both teams.
In another derby, Cardiff welcome Cardiff Met, formerly UWIC to the Arms Park while Whitland take on Aberavon, Ebbw Vale host fellow Gwent side Newbridge and Llandovery travel to Bedwas in the other all Premiership tie.
North Wales side RGC 1404 will be hoping to win their first ever SWALEC Cup game but they face a difficult tie away to Swansea, while the remaining round one fixtures see Llanharan take on Beddau, Bonymaen visit Newport, Narberth clash with Premiership side Carmarthen and Blackwood host Pontypool.
Defending champions Cross Keys as well as Bargoed, Glamorgan Wanderers, Neath and Tata Steel all have byes in the first round.
The sides involved will have to wait for their cup run to start though with the round one fixtures taking place the weekend of January 26 2013..
This week on the Principality Premiership Podcast, WRU TV's Graeme Gillespie talks to Carmarthen Quins head coach Louie Tonkin who is aiming to close the gap on leading duo, Pontypridd and Ebbw Vale, with victory against Bridgend tomorrow.
Christmas has come early at Glynneath rugby club, one of a number around Wales who have received an array of merchandise and equipment this December courtesy of the Welsh Rugby Union's £750,000 participation points scheme.
The WRU have been delivering on the scheme - which gives individual clubs access to up to £5,000 worth of supplies and equipment each for the 2014/2015 season - over the last two weeks and today (Friday) were received by a special guest in Glynneath, club president and pitch marker Max Boyce.
The Welsh Rugby Union has signed a new four year deal with specialist equipment supplier Rhino Rugby, which is set to benefit both the grass roots game in Wales and the national squad in equal measure.
We watch the new grass growing and being stitched together in this week's Principality Welsh Rugby Union Podcast. We speak to Millennium Stadium groundsman Lee Evans, Wales great Ieuan Evans gives an overview on the new strategy announced by head of rugby Josh Lewsey, while we also hear from Bedwas, Aberavon and Carmarthen Quins in the Principality Premiership.
Wales assistant coach Rob Howley was welcomed with open arms by the staff and players at Crymych recently when he hosted a training session in memory of former club captain and coach, Glyndwr Richards.
We hear about the WRU's annual report and some exciting new plans for schools and clubs round Wales in this week's Principality Welsh Rugby Union Podcast. WRU finance director Steve Phillips explains the money side, while head of rugby Josh Lewsey explains his new strategy for schools and clubs. We also get reaction from all round Wales.