In the SWALEC Cup, last year's beaten finalists Pontypridd face a difficult trip to Llanelli in a match that will see one of Welsh rugby's cup giants exit the competition at the first hurdle.
Ponty fell to a surprise defeat against Cross Keys in last season's final at the Millennium Stadium and will have to overcome the ultimate cup kings, 14 times winners Llanelli on their own patch in order to progress to round two.
Elsewhere, rivals Bridgend and Bridgend Athletic clash at Brewery Field with local bragging rights at stake. The Ravens started their Premiership campaign with a win over Llanelli last weekend but the local derby will surely bring out the best in both teams.
In another derby, Cardiff welcome Cardiff Met, formerly UWIC to the Arms Park while Whitland take on Aberavon, Ebbw Vale host fellow Gwent side Newbridge and Llandovery travel to Bedwas in the other all Premiership tie.
North Wales side RGC 1404 will be hoping to win their first ever SWALEC Cup game but they face a difficult tie away to Swansea, while the remaining round one fixtures see Llanharan take on Beddau, Bonymaen visit Newport, Narberth clash with Premiership side Carmarthen and Blackwood host Pontypool.
Defending champions Cross Keys as well as Bargoed, Glamorgan Wanderers, Neath and Tata Steel all have byes in the first round.
The sides involved will have to wait for their cup run to start though with the round one fixtures taking place the weekend of January 26 2013..
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