In the SWALEC Cup, last year's beaten finalists Pontypridd face a difficult trip to Llanelli in a match that will see one of Welsh rugby's cup giants exit the competition at the first hurdle.
Ponty fell to a surprise defeat against Cross Keys in last season's final at the Millennium Stadium and will have to overcome the ultimate cup kings, 14 times winners Llanelli on their own patch in order to progress to round two.
Elsewhere, rivals Bridgend and Bridgend Athletic clash at Brewery Field with local bragging rights at stake. The Ravens started their Premiership campaign with a win over Llanelli last weekend but the local derby will surely bring out the best in both teams.
In another derby, Cardiff welcome Cardiff Met, formerly UWIC to the Arms Park while Whitland take on Aberavon, Ebbw Vale host fellow Gwent side Newbridge and Llandovery travel to Bedwas in the other all Premiership tie.
North Wales side RGC 1404 will be hoping to win their first ever SWALEC Cup game but they face a difficult tie away to Swansea, while the remaining round one fixtures see Llanharan take on Beddau, Bonymaen visit Newport, Narberth clash with Premiership side Carmarthen and Blackwood host Pontypool.
Defending champions Cross Keys as well as Bargoed, Glamorgan Wanderers, Neath and Tata Steel all have byes in the first round.
The sides involved will have to wait for their cup run to start though with the round one fixtures taking place the weekend of January 26 2013..
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
Girls in North Wales have two great rugby role models in WRU Regional Coordinator Rachel Taylor and Rhyl High School Hub Officer Ale Lewis, both helping to increase opportunities for women and girls in Welsh rugby.
In this weeks podcast, Bargoed captain Leigh Meades and Swansea head coach Richard Lancaster chat to WRU TV's Graeme Gillespie who hears that both camps are determined to move up the Principality Premiership table.
One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
This week on the Pick and Go Podcast, WRU TV's Graeme Gillespie is joined by South Wales Argus rugby writer Chris Kirwan to preview this weekend's Principality Premiership action. Aberavon winger Steffan Andrews also makes an appearance.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
This week in the Principality Premiership, all roads lead to the new pitch at Sardis Road where Pontypridd take on Merthyr in the most highly anticipated game of the season. WRU TV's Graeme Gillespie previews the big clash, along with all the other Premiership games this weekend, with guest Ioan Dyer.
The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.
The Welsh Rugby Union is calling on all grassroots clubs to nominate a club integrity officer who will be invited to anti-doping awareness workshops and receive information in order to educate their players and coaches