Up front there is a shuffle in the front row with Will Griff-John coming in at tight head prop and in the back row Garrick Armstrong moves from openside flanker to blindside with Andrew Bradbury coming in at open-side.
On the bench there are new faces with Jack Dando and Ross Gibbon joining the squad for the first time this season.
"We feel we have made great leaps forward this season but we need to back that with wins," said Matthew Bolton, Wanderers head coach, before the trip to Bridgend Athletic.
"We spent a lot of time on the technical issues of our game this week. We'll be looking for that work to have paid off on Saturday," added manager Luke Burton.
Glamorgan Wanderers: 15 Ed Doe 14 Nick McGowan 13 Loren Quick 12 Lloyd Chalke 11 Owen Marshall 10 Ianto Griffiths 9 Luke O'Brien; 1 Rhys Jenkins 2 Jac Hopkins 3 Will Griff-John 4 Alex Luff (c) 5 Lloyd King 6 Garrick Armstrong 7 Andrew Bradbury 8 Patrick Marks
Replacements: 16 Jack Dando 17 Tom Crosse 18 Ross Gibbon 19 Mike Stephens 20 Garyn Lucas