Aberavon earned a spot in the second round after narrolwly beating Bridgend in the last round.
SWALEC Cup champions Pontypridd have drawn a home tie in Round Two against the winners of the rearranged Newport v Bonymaen clash which will take place on Tuesday (7.30pm).
Cup kings Llanelli, who saw off Tata Steel 38-10 in Round One last weekend, must travel to Cardiff Met who were 14-7 victors over Blackwood to go through to the last 16.
Chris Davey, Cardiff Met head coach said, "I'm really pleased. It's always the objective for the Championship sides to test ourselves against those from the Premiership. That's the hope we always have when these draws come around. To play against a club with the history of Llanelli will be a big challenge. They are a good side who play a lot of running rugby and they're going well in the league this season. But we had a good win in the last round and like to throw the ball around ourselves. If we can get an improvement in the weather and a decent track then I think we'll have a good game."
Cardiff face another club with a big history in Newbridge, at the Arms Park, while the other Principality Premiership sides already through to the next round - Llandovery, Aberavon and Cross Keys must secure away wins to progress further in the competition. Llandovery play the winners of Llanharan v Tondu (Saturday, 2.30), Aberavon travel to Narberth and Cross Keys must wait on the outcome of the rearranged match between Bargoed and fellow Premiership side Bedwas on Saturday (2.30).
Cardiff director of rugby Martyn Fowler said: "We are pleased to avoid one of the other Premiership sides but Newbridge at home won't be easy. We will need to turn up with the right attitude, play the game in the right areas and make sure we give it our all. At the start of the season we set ourselves goals to be in the top six and to have a good run in the SWALEC Cup. It gives our players the chance to play against sides we don't normally come up against and that's certainly the case with Newbridge. We were knocked out of the Cup by a Championship side last year so we'll be moving heaven and earth to make sure it doesn't happen again."
There will be at least one SWALEC Championship side in the Cup quarter-finals with previous finalists Ebbw Vale taking on RGC 1404 at Eugene Cross Park. RGC General Manager Rupert Moon said, "This is the biggest SWALEC Cup date in our history so far having entered the competition last season. It would have been nice to reward our fans with a home draw but we're certainly up for the tough challenge Ebbw Vale will bring to this encounter. We've lost both of our matches against them this season but as I know from my playing days with Llanelli, anything can happen in cup rugby and it's not over until it's over."
SWALEC Cup Round Two draw (matches to be played weekend of February 15)
Cardiff Met v Llanelli
Carmarthen v Bridgend Athletic
Pontypridd v Newport / Bonymaen
Llanharan/ Tondu v Llandovery
Narberth v Aberavon
Bargoed / Bedwas v Cross Keys
Cardiff v Newbridge
Ebbw Vale v RGC 1404
After a lengthy and successful playing career with the Scarlets, RGC 1404 forwards coach Phil John is rapidly making a name for himself as a coach in north Wales. WRU TV's Graeme Gillespie hears how his fledging career in the hot seat is going and discovers a man on a mission.
Bedwas had to overcome a stubborn Carmarthen Quins side before winning the Foster's Challenge Cup final in Bridgend with a 23-18 victory. Bedwas captain Nicky Griffiths pays tribute to his side who have claimed the club's first piece of silverware in the modern era.
Team coach Brett Davey is aiming to keep his unbeaten run in cup finals at Principality Stadium intact when his side take on Amman United in the WRU Bowl final, after he guided Caerphilly to a 20-14 win against Cilfynydd in the semi-finals.
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Equal access to facilities and resources at St Helen's has seen Swansea Women flourish since being welcomed with open arms last July. Swansea RFC chairman Stephen Hughes and women's captain Siwan Lillicrap are delighted to see rapid progress being made on and off the pitch.
It's back to the Principality Premiership for our top clubs this weekend. This week GTFM's Ioan Dyer takes his Pontypridd hat off - temporarily at least - and looks ahead to the programme with WRU TV's Graeme Gillespie
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Ospreys and Wales duo Rhys Webb and Scott Baldwin return to their home town club Bridgend Ravens as they prepare for life after their rugby playing careers by undertaking their coaching badges at the Principality Premiership outfit.
The Urdd were unveiled as the WRU's national schools sevens partner at Pencoed yesterday. A flagship event for the new partnership will be the Urdd WRU 7s at Pencoed held over three days on April 4, 5, 6.
The second phase of the Principality Premiership kicked off last week with the introduction of two tiers. In this week's podcast Aberavon No 8 Chris Davies tells WRU TV's Graeme Gillespie he's had to change his game while Cross Keys head coach Greg Woods says his side still have plenty to aim for.
Wales' 2017 Under Armour Series fixtures against Australia, Georgia, New Zealand and South Africa have been confirmed alongside news of earlier access to tickets and significant price reductions for the Principality Stadium matches.
Aberavon moved to within a point of table-topping Merthyr in Tier 1 of the Principality Premiership to add even further spice to their trip to The Wern this weekend with a 24-21 win at Carmarthen Quins.