Aberavon earned a spot in the second round after narrolwly beating Bridgend in the last round.
SWALEC Cup champions Pontypridd have drawn a home tie in Round Two against the winners of the rearranged Newport v Bonymaen clash which will take place on Tuesday (7.30pm).
Cup kings Llanelli, who saw off Tata Steel 38-10 in Round One last weekend, must travel to Cardiff Met who were 14-7 victors over Blackwood to go through to the last 16.
Chris Davey, Cardiff Met head coach said, "I'm really pleased. It's always the objective for the Championship sides to test ourselves against those from the Premiership. That's the hope we always have when these draws come around. To play against a club with the history of Llanelli will be a big challenge. They are a good side who play a lot of running rugby and they're going well in the league this season. But we had a good win in the last round and like to throw the ball around ourselves. If we can get an improvement in the weather and a decent track then I think we'll have a good game."
Cardiff face another club with a big history in Newbridge, at the Arms Park, while the other Principality Premiership sides already through to the next round - Llandovery, Aberavon and Cross Keys must secure away wins to progress further in the competition. Llandovery play the winners of Llanharan v Tondu (Saturday, 2.30), Aberavon travel to Narberth and Cross Keys must wait on the outcome of the rearranged match between Bargoed and fellow Premiership side Bedwas on Saturday (2.30).
Cardiff director of rugby Martyn Fowler said: "We are pleased to avoid one of the other Premiership sides but Newbridge at home won't be easy. We will need to turn up with the right attitude, play the game in the right areas and make sure we give it our all. At the start of the season we set ourselves goals to be in the top six and to have a good run in the SWALEC Cup. It gives our players the chance to play against sides we don't normally come up against and that's certainly the case with Newbridge. We were knocked out of the Cup by a Championship side last year so we'll be moving heaven and earth to make sure it doesn't happen again."
There will be at least one SWALEC Championship side in the Cup quarter-finals with previous finalists Ebbw Vale taking on RGC 1404 at Eugene Cross Park. RGC General Manager Rupert Moon said, "This is the biggest SWALEC Cup date in our history so far having entered the competition last season. It would have been nice to reward our fans with a home draw but we're certainly up for the tough challenge Ebbw Vale will bring to this encounter. We've lost both of our matches against them this season but as I know from my playing days with Llanelli, anything can happen in cup rugby and it's not over until it's over."
SWALEC Cup Round Two draw (matches to be played weekend of February 15)
Cardiff Met v Llanelli
Carmarthen v Bridgend Athletic
Pontypridd v Newport / Bonymaen
Llanharan/ Tondu v Llandovery
Narberth v Aberavon
Bargoed / Bedwas v Cross Keys
Cardiff v Newbridge
Ebbw Vale v RGC 1404
Bedwas head coach Steve Law and players Nicky Griffiths and Alun Rees extol the virtues of the close knit club as they prepare to host third place RGC 1404 - who are one place head of them on the Principality Premiership points table - on Saturday.
The second WRU disability rugby pilot has been delivered, this time in Caerphilly schools, culminating in a festival at the Caerphilly Centre of Sporting Excellence, Ystrad Mynach tomorrow. Plans are in place to set up a Disability Rugby Club in Newbridge to provide long-term playing opportunities.
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One of the newest members of the Principality Premiership, Bargoed admit it's proving to be a steep learning curve at the highest level, but are determined to become a force to be reckoned with. WRU TV visited the club last weekend when they took on Llanelli.
This week on the Pick and Go Podcast, WRU TV's Graeme Gillespie is joined by South Wales Argus rugby writer Chris Kirwan to preview this weekend's Principality Premiership action. Aberavon winger Steffan Andrews also makes an appearance.
Table-topping Aberavon travel to north Wales to tackle RGC 1404 as both teams defend unbeaten starts to the season in the Principality Premiership. WRU TV's Graeme Gillespie visited the Wizards to see how their preparations were going for the game of the weekend.
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The Half a Game initiative is currently sweeping across Wales and proving a major success. The scheme aims to give every young player at least half a game every weekend. WRU TV recently visited a festival in Narberth where clubs have fully embraced the initiative.
Both Bargoed and Swansea were seeking their first win of the Principality Premiership season this afternoon. It proved a fruitful day for the hosts - not only did they win, but Bargoed claimed a try bonus point.
Cardiff managed to keep their unbeaten record at home intact, but only just as Bridgend made them work extremely hard before the Blue and Blacks secured a hard fought Principality Premiership win at the BT Sport Arms Park last night.
Former Wales back row Andy Powell gives a guided tour of The Wern, home of Merthyr RFC, who are determined to prove a lot of people wrong and make their mark in their first season in the Principality Premiership.
Beating Merthyr has boosted Carmarthen Quins hopes of reaching a top eight spot in the Principality Premiership. Quins captain Haydn Pugh is delighted with his team's progress and is determined that everyone from the Under 6s through to the senior team, enjoys the ride.
The race for a top half finish in the new look Principality Premiership is set for a dramatic finish over the Christmas and New Year period with only three of the 16 clubs definitely ruled out of the reckoning.
The Welsh Rugby Union is calling on all grassroots clubs to nominate a club integrity officer who will be invited to anti-doping awareness workshops and receive information in order to educate their players and coaches