Following their double-securing win over Swansea last week, Neath bring in centre Kyle Davies, props Nicky Downs and Marc Jones and back-rowers Steffan Jones and Leon Ward for their trip to Carmarthen.
Coach Patrick Horgan said: "We were pleased to get back to winning ways last week at Swansea but are realistic too in acknowledging the difficult time the Whites are enduring at the moment.
"We are looking to build some continuity into our selection where injuries are not making things straightforward for us.
Nonetheless, the squad is really pulling together and, if sheer hard work is a measure, deserves to succeed.
"We are expecting a big test at Carmarthen who have proved themselves a match for anyone in this League. They are always well-organised and will start as favourites and our boys need to take the game to them."
Swansea are another team to have struggled so far this season and they face a difficult trip to Pandy Park to take on Cross Keys.
Greg Woods' side are really struggling with injuries with 11 players out through injury though they are able to call on the likes of Rob Nash, Gerwyn Price and Steffan Jones in their starting XV.