With some players stepping up to regional level, plus some injury issues, Llanelli coach Anthony Buchanan shuffles his pack for the clash with Quins.
Dale Ford who came through a successful 40 minute stint against Cardiff, starts on the wing with Kyle Evans on the opposite flank. Diggy Bird also makes a return from injury and is partnered by live wire scrum half Justin James.
Another player on the comeback trail is second row Joel Galley who could make a start from the bench and will be joined by local boys Lawrence Reynolds, Stuart Morris and Berian Watkins.
Carmarthen secured another win against Cross Keys last Saturday and will test the home side's defence to the full.
Wales Sevens star Jason Harries will be the main threat as he looks to maintain the form that saw him run in a hat-trick against Swansea recently.
Llanelli: 15 Jonathan Lewis 14 Dale Ford 13 Christopher Keenan 12 Steffan Hughes 11 Kyle Evans 10 David Bird 9 Justin James, 1 Rhys Thomas 2 Craig Hawkins 3 Aled Hopkins 4 Adam Powell 5 Nathan White 6 Stuart Leach 7 Duane Eager 8 Edward Price.
Replacements: Thomas Sloane, Gregory George, Berian Watkins, Joel Galley, Lawrence Reynolds, Ryan Jones, Stuart Morris, Bowdy Davies.
Carmarthen: 15 Darren Daniel 14 Rhys Thomas 13 Andrew Banfield 12 Rheon James 11 Jason Harries 10 James Dixon 9 Rhodri Wells, 1 Ian Jones (c) 2 Ricky Guest 3 Trystan Davies 4 Carwyn Jones 5 Haydn Pugh 6 Aidan Laxton 7 James Davies 8 Luke Joseph.
Replacements: Andrew Beaujean, Daniel Smith, Gavin Evans, Elis Lloyd, Huw Rees, Christopher Banfield, Alex Pickersgill.